Stem cells fight cellular inflammation (the main source of pain) that results in decreased score on pain scale, reduction of joint inflammation, pain, swelling, stiffness, and overall an improved physical condition.
After only a few days, most patients recalled a systemic anti-inflammatory effect, improved therapeutic response, and increase range of motion (especially those with knee problems or stiff limbs).
Stem cells aid in host endogenous repair. This means it activates our own stem cells and other cells to help heal, repair and regenerate.
A traditional knee surgery recovery can take up months, on the other hand, stem cell therapy recovery is almost immediate and patients are able to go back to their normal activities the next day. In most cases, with the newfound energy after the therapy, patients want to return to their normal work load yet we recommend allowing the cells to repair at least 21 days before jumping into sports or high-intensity training.
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1. Aigner T, Stove J. Collagens-major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair. Adv Drug Deliv Rev. 2003;55:1569-93.
2. Mow VC, Setton LA. Mechanical properties of normal and osteoarthritis articular cartilage. In: Brandt KD, Doherty M, Lohmander LS, editors. Osteoarthritis: Oxford: Oxford University Press. 1998. 108-22.
3. Arden N, Nevitt MC. Osteoarthritis: epidemiology. Best Pract Res Clin Rheumatol. 2006;20:3-25.
4. Chen YC, Chang CH. Clinical application of mesenchymal stem cells for cartilage regeneration. Plast Aesthet Res. 2020. 7:49.
5. Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Muscoloeskelet Dis. 2013. 5:77-94.
6. Kappor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011. 7:33-42.
7. Kangari P, Talaei-Khozani T, Razaghian-Jahromi I, Mahboobeh R. Mesenchymal stem cells: amazing remedies for bone and cartilage defects. Stem CellStem Cell Res Ther. 2020. 11(1):492.
8. Saeed H, Ahsan M, Saleem Z, et al. Mesenchymal stem cells (MSCs) as skeletal therapeutics -and update. J Biomed Sci. 2016. 23(1):41.
9. Hofer HR, Tuan RS. Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies. Stem Cell Res Ther. 2016. 7(1):131.
10. Mea DN. Human bone marrow stormal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood. 2002. 99:3838-43.
11. Spaggiari GM, Capobianco A, Becchetti S, Mingari L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2- induced NK cell-proliferation. Blood. 2006. 107:1484-90-
12. Yagi HS-GA, Parekkadan B, Kitagawa Y, et al. Mesenchymal stem cells: mechanisms of immunomodulation and homing. Cell Transplat. 2010. 19:667-79.
13. Sun YQDM, He J, Zeng QX, et al. Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice. Stem Cells. 2012;30:2692-9.
14. Chabannes DHM, Merieau E, Rossignol J, et al. A role for heme oxygenase-1 in the immunosuppressive efect of adult rat and human mesenchymal stem cells. Blood. 2007. 110:3691-4.
15. Fu QLCY, Sun SJ, Zeng QX, et al. Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhibitis. Allergy. 2012. 67(10):1215-22.
16. Antebi B, Pelled G, Gazit D. Stem cell therapy for osteoporosis. Curr Osteopor Rep. 2014. 12(1):41-7.
17. Langdahl B, Ferrari S, Dempster DW. Bone modeling and remodelling: potential as therapeutic targets for the treatment of osteoporosis. Ther Adv Muscolosk Dis. 2016. 8(6):225-35.
18. Pitchford SC, Furze RC, Jones CP, Wengner AM, Rakin SM. Differential mobilization of subsets of progenitor cells from the bone marrow. Cell Stem Cell. 2009. 4(1):62-72.
19. de Girolamo L, Lucarelli E, Alessandri G, et al. Mesenchymal stem/stromal cells: a new “cell as drugs” paradigm. Efficacy and critical aspects in cell therapy. Curr Pharm Des. 2013. 19(3): 2459-73.
20. Qin Y, Guan J, Zhang C. Mesenchymal stem cells: mechanisms and role in bone regeneration. Postgrad Med J. 2014. 90(1069):643-7.